R&D roadmap for green hydrogen ecosystem in India

The Ministry of New and Renewable Energy has published the R&D; Roadmap for Green Hydrogen Ecosystem in India. This document was published on 13th October, 2023. One of the central pillars of the National Green Hydrogen Mission is the establishment of a supportive research and innovation ecosystem for green hydrogen …

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

Traditional approaches for development of antibodies are poorly suited to combating the emergence of novel pathogens, as they require multiple steps of laborious optimization and process adaptation for clinical development. Here, we describe the simultaneous use of two state-of-the-art technologies to rapidly generate and validate antibodies against Middle East Respiratory …

Sacrificial amphiphiles: Eco-friendly chemical herders as oil spill mitigation chemicals

Crude oil spills are a major threat to marine biota and the environment. When light crude oil spills on water, it forms a thin layer that is difficult to clean by any methods of oil spill response. Under these circumstances, a special type of amphiphile termed as “chemical herder” is …

Cafeteria diet impairs expression of sensory-specific satiety and stimulus-outcome learning

A range of animal and human data demonstrates that excessive consumption of palatable food leads to neuroadaptive responses in brain circuits underlying reward. Unrestrained consumption of palatable food has been shown to increase the reinforcing value of food and weaken inhibitory control; however, whether it impacts upon the sensory representations …

Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009–15

Antimicrobial resistance (AMR) is a priority for surveillance in bacterial infections. For leprosy, AMR has not been assessed because Mycobacterium leprae does not grow in vitro. We aim to obtain AMR data using molecular detection of resistance genes and to conduct a prospective open survey of resistance to antileprosy drugs …

Advantages of eutectic alloys for creating catalysts in the realm of nanotechnology-enabled metallurgy

The nascent field of nanotechnology-enabled metallurgy has great potential. However, the role of eutectic alloys and the nature of alloy solidification in this field are still largely unknown. To demonstrate one of the promises of liquid metals in the field, we explore a model system of catalytically active Bi-Sn nano-alloys …

CRISPR babies: When will the world be ready?

Efforts to make heritable changes to the human genome are fraught with uncertainty. Here’s what it would take to make the technique safe and acceptable. Original Source

A Statistical Timetable for the Sub–2-Hour Marathon

Breaking the sub–2-h marathon in an official event has attracted growing interest in recent times with commercial and international momentum building.http://www.indiaenvironmentportal.org.in/content/455280/untapped-potential-forest-ecosystem-services-for-achieving-sdg-15/ Here it is shown that predicting how likely and when the sub–2-h barrier will be broken are statistically coupled considerations. Original Source

Microplastics in drinking-water

Microplastics are increasingly found in drinking water, but there is no evidence so far that this poses a risk to humans, according to a new assessment by the World Health Organization. However, the United Nations body warned against complacency because more research is needed to fully understand how plastic spreads …

Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. While deer and elk PrP …

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo–electron microscopy (EM), followed by resistance selection and reverse genetics, …

Exploring the therapeutic effects of yoga and its ability to increase quality of life

The objective of this study is to assess the findings of selected articles regarding the therapeutic effects of yoga and to provide a comprehensive review of the benefits of regular yoga practice. As participation rates in mind-body fitness programs such as yoga continue to increase, it is important for health …

Curd-peptide based novel hydrogel inhibits biofilm formation, quorum sensing, swimming mortility of multi-antibiotic resistant clinical isolates and accelerates wound healing activity

The search for a bioactive natural antibacterial agent with wound healing properties is a common practice for the development of new-generation molecules. Antimicrobial peptides are a good alternative to antibiotics and easy-to-form hydrogels under self-assembled conditions without pH adjustment. With this in mind, the peptide pool was extracted from a …

Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro

There is evidence that pathogenic bacteria can adapt to antiseptics upon repeated exposure. More alarming is the concomitant increase in antibiotic resistance that has been described for some pathogens. Unfortunately, efects of adaptation and cross-adaptation are hardly known for oral pathogens, which are very frequently exposed to antiseptics. Therefore, this …

Nectar robbing in bellflower (Sesamum radiatum) benefited pollinators but unaffected maternal function of plant reproduction

Nectar robbing – foraging nectar illegitimately – has negative, neutral, or positive efects on maternal function of plant reproduction and/or on pollinators. It has been suggested that nectar robbing has a non-negative efect on maternal function of plant reproduction in autogamous and mixed breeding plants; however this hypothesis requires deeper …

Symbolic representation of numerosity by honeybees (Apis mellifera): matching characters to small quantities

The assignment of a symbolic representation to a specific numerosity is a fundamental requirement for humans solving complex mathematical calculations used in diverse applications such as algebra, accounting, physics and everyday commerce. Here we show that honeybees are able to learn to match a sign to a numerosity, or a …

Climate research for development in Africa using climate science to drive Africa’s development

The Assessment Reports of the Intergovernmental Panel on Climate Change (IPCC) – the body widely recognized as the international authority on climate change — give clear evidence of increased warming across Africa. The reports put forward a powerful case that increases in global temperatures are the result of human-induced climate …

Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international casecontrol study

The rapid increase in mobile telephone use has generated concern about possible health risks related to radiofrequency electromagnetic fields from this technology. An interview-based case Original Source

Room-temperature ferromagnetic Sr3YCo4O10+δ and carbon black reinforced polyvinylidenefluoride composites toward high performance electromagnetic interference shielding

Ever since the electronic revolution, electronic devices have become an indispensable part of common man’s life. The rapid increase in the usage of such devices as well as instruments dealing with electromagnetic (EM) waves generates a serious issue of EM interference (EMI). Scientists have turned their attention toward EMI as …

Conflict of interest reporting by authors involved in promotion of off-label drug use: An analysis of journal disclosures

Aaron Kesselheim and colleagues investigate conflict of interest disclosures in articles authored by physicians and scientists identified in whistleblower complaints alleging illegal off-label marketing by pharmaceutical companies. Original Source

Potential of fungi isolated from the dumping sites mangrove rhizosphere soil to degrade polythene

Polythene is the most widely used plastic around the globe. Among the total plastic waste generated, polythene contributes the maximum share (64%). Various strategies/methods are being utilized to deal with the increasing rate of plastic waste, but among all the methods, bioremediation is regarded as the ecofriendly and widely accepted …

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