Formaldehyde is a potent proteotoxic stressor causing rapid heat shock transcription factor 1 activation and Lys48-linked polyubiquitination of proteins
Endogenous and exogenous formaldehyde (FA) has been linked to cancer, neurotoxicity, and other pathophysiologic effects. Molecular and cellular mechanisms that underlie FA-induced damage are poorly understood. In this study, we investigated whether proteotoxicity is an important, unrecognized factor in cell injury caused by FA.