Order of the National Green Tribunal regarding pollution of Godavari river, Telangana, 29/05/2025

Order of the National Green Tribunal in the matter of News Item titled "Telangana: Deepening pollution crisis in Godawari threatens lives livelihoods appearing in the Telangana Today dated 13.05.2025" dated 29/05/2025. The application was registered suo-motu on the basis of the news item titled Telangana: Deepening pollution crisis in Godawari …

Genetic diversity of highly pathogenic H5N8 avian influenza viruses at a single overwintering site of migratory birds in Japan, 2014/15

We isolated eight highly pathogenic H5N8 avian influenza viruses (H5N8 HPAIVs) in the 2014/15 winter season at an overwintering site of migratory birds in Japan. Genetic analyses revealed that these isolates were divided into three groups, indicating the co-circulation of three genetic groups of H5N8 HPAIV among these migratory birds. …

Pathogenesis and transmission of novel HPAI H5N2 and H5N8 avian influenza viruses in ferrets and mice

A novel highly pathogenic avian influenza (HPAI) H5N8 virus, first detected in January 2014 in poultry and wild birds in South Korea, has spread throughout Asia and Europe, and caused outbreaks in Canada and the United States by the end of the year. The spread of H5N8 and the novel …

The evolution of Ebola virus: Insights from the 2013–2016 epidemic

The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning of large-scale realtime molecular epidemiology. Here, we show how evolutionary analyses of Ebola virus genome sequences provided key insights …

Molecular epidemiology of human enterovirus 71 at the origin of an epidemic of fatal hand, foot and mouth disease cases in Cambodia

Human enterovirus 71 (EV-A71) causes hand, foot and mouth disease (HFMD). EV-A71 circulates in many countries and has caused large epidemics, especially in the Asia-Pacific region, since 1997. In April 2012, an undiagnosed fatal disease with neurological involvement and respiratory distress occurred in young children admitted to the Kantha Bopha …

Perspectives on Hepatitis B studies with chimpanzees

Chimpanzees have been shown to be exquisitely susceptible to human hepatitis viruses, without themselves developing clinical illness, thus providing an important model for studies on these agents. Chimpanzees have contributed substantially to human welfare by making possible the development of hepatitis B vaccines, which now prevent development of cirrhosis and …

A unified framework for the infection dynamics of zoonotic spillover and spread

A considerable amount of disease is transmitted from animals to humans and many of these zoonoses are neglected tropical diseases. As outbreaks of SARS, avian influenza and Ebola have demonstrated, however, zoonotic diseases are serious threats to global public health and are not just problems confined to remote regions. There …

Nigeria: Delta Quarantines 55 Over Lassa Fever Death

Asaba — Fifty-five persons are currently under watch in Asaba, the Delta State capital, for coming in contact with the medical doctor who died recently of Lassa fever in neighbouring Anambra State. The initial figure was 32. The Commissioner for Health, Dr. Nicholas Azinge, who made the disclosure yesterday in …

Canine distemper virus: An emerging disease in wild endangered Amur tigers (Panthera tigris altaica)

Fewer than 500 Amur tigers (Panthera tigris altaica) remain in the wild. Due to low numbers and their solitary and reclusive nature, tiger sightings across their range in the Russian Far East and China are rare; sightings of sick tigers are rarer still. Serious neurologic disease observed in several wild …

Standing on the shoulders of giant viruses: Five lessons learned about large viruses infecting small eukaryotes and the opportunities they create

Viruses are generally considered to be amongst the smallest bioactive particles; dating back to the original observations, including those of luminaries such as Ivanosky and Beijerinck, size has always been at issue within the definition, a tradition that continued for many years. It was thus a surprise to the scientific …

Structural basis of Zika virus helicase in recognizing its substrates

The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern. No specific vaccines or drugs are currently available to treat ZIKV infection. The ZIKV …

After rains, fever turns 'viral' in 3 districts

Alwar: Following recent torrential rains, viral fever has Alwar, Bharatpur and Dholpur in its grip. But, Bharatpur is the worst affected among the three districts in the state. Heavy rains in the area brought viral infections in its wake, with hospitals witnessing an increase in cases of sneezing, cough and …

Expanded Indian National Rotavirus Surveillance Network in the context of Rotavirus Vaccine introduction

The objective of the study was to extend a nation-wide rotavirus surveillance network in India, and to generate geographically representative data on rotaviral disease burden and prevalent strains. Original Source

Undiscovered bat hosts of Filoviruses

Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high biodiversity of potential hosts in temporally dynamic environments of equatorial Africa contributes to sporadic, unpredictable outbreaks that have …

Human survivors of disease outbreaks caused by Ebola or Marburg viruses exhibit cross-reactive and long-lived antibody responses

A detailed understanding of serological immune responses to Ebola and Marburg virus infections will facilitate the development of effective diagnostic methods, therapeutics and vaccines. We examined antibodies from Ebola or Marburg survivors 1-14 years after recovery from disease, by using a microarray that displayed recombinant nucleoprotein (NP), viral protein 40 …

Progress towards protection from highly lethal Ebola, Marburg viruses

Ebola and Marburg filovirus disease outbreaks have typically occurred as isolated events, confined to central Africa. However, the recent Ebola epidemic spread to several African countries, and caused 11,000 deaths. That epidemic underscored the need to develop vaccines and therapeutics that could be used to fight future disease outbreaks. Now …

Has Rift Valley fever virus evolved with increasing severity in human populations in East Africa?

Rift Valley fever (RVF) outbreaks have occurred across eastern Africa from 1912 to 2010 approximately every 4–15 years, most of which have not been accompanied by significant epidemics in human populations. However, human epidemics during RVF outbreaks in eastern Africa have involved 478 deaths in 1998, 1107 reported cases with …

Cooperative effect of the VP1 amino acids 98E, 145A and 169F in the productive infection of mouse cell lines by enterovirus 71 (BS strain)

Researchers have identified key genes behind the infectivity of a virus that causes hand, foot, and mouth disease. Humans are the only known mammalian host, but in 2014, strains were bred that were capable of infecting mice and primate cell lines. These strains had mutant versions of the virus coat …

Structural basis of potent Zika–dengue virus antibody cross-neutralization

Zika virus is a member of the flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia.

Identification of Zika Virus and Dengue Virus dependency factors using functional genomics

The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/ Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as …

Low protective efficacy of the current Japanese Encephalitis vaccine against the emerging genotype 5 Japanese Encephalitis virus

The human disease Japanese encephalitis (JE) can be prevented by vaccination, although it is not entirely clear if the emerging JEV G5 genotype can be controlled using the vaccine based on the G3 genotype. Consequently, we systematically compared G3 and G5 cross-neutralizing immune responses in vaccinated humans and, separately, cross-protective …

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