Medical Research

Order of the National Green Tribunal regarding deterioration of Nayar river, Uttarakhand, 05/06/2025

Order of the National Green Tribunal in the matter of In Re: News Item titled "Nayar river is vanishing - a yatra reveals conservation goes beyond science and policy" appearing in ‘The Down To Earth’ dated 03.06.2025. The original application was registered suo-motu based on the news item titled "Nayar …

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective …

Microbiological characterisation of co-infections and secondary infections in patients with COVID-19 is lacking, and antimicrobial use is high. The researchers aimed to describe microbiologically confirmed co-infections and secondary infections, and antimicrobial use, in patients admitted to hospital with COVID-19. Original Source

Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low Prevalence Communities and Reveal Durable Humoral Immunity

Immunity against COVID-19 may persist for at least five months after being infected with the SARS-CoV-2 virus, according to a study led by an Indian-origin researcher in the US. The researchers from the University of Arizona studied the production of antibodies from a sample of nearly 6,000 people infected with …

SNBNCBS develops a “No-touch” &“Painless” device for non-invasive screening of bilirubin level in newborns

The device called “AJO-Neo” is developed by Professor Samir K. Pal &his group at S.N. Bose National Centre For Basic Sciences (SNBNCBS), Kolkata, an autonomous research Institute under the Department of Science and Technology (DST), Government of India. According to the study conducted by the SNBNCBS team in NRS medical …

Genomic Data Policy Framework and Ethical Tensions

Genomic data collection is accelerating in historically understudied and excluded populations. The information will fill knowledge gaps, spur medical discoveries and lead to more targeted and appropriate care; however, it comes with significant risk if ungoverned. Insufficient genomic data policies expose communities to the risk that certain actors will extract …

Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data

The objective of the study wast to assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen.

Lack of efficacy of hydroxychloroquine in covid-19

Studies in mild-to-moderate cases as well as severe disease leave us still searching for a magic pill. (Editorial)

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial

The objective of the study was to assess the efficacy and safety of hydroxychloroquine plus standard of care compared with standard of care alone in adults with coronavirus disease 2019 (covid-19).

ICMR-NIV Pune develops and validates the indigenous IgF ELISA test "COVID KAVACH ELISA" for antibody detection for COVID-19

The scientists at ICMR-NIV, Pune have developed and validated the completely indigenous IgG ELISA test for antibody detection for SARS-CoV-2. On external validation, the IgG test kit produced by ICMR-NIV, Pune has been found to have sensitivity and specificity of 98.7% and 100% respectively. ELISA test has the advantage of …

Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered 2 patient cohort and their implications

The COVID-19 pandemic caused by SARS-CoV-2 coronavirus threatens global public health. Currently, neutralizing antibodies (NAbs) versus this virus are expected to correlate with recovery and protection of this disease. However, the characteristics of these antibodies have not been well studied in association with the clinical manifestations in patients .Original Source

Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test

It has been reported that several cases recovered from COVID-19 tested positive for SARS-CoV-2 after discharge (re-detectable positive, RP), however the clinical characteristics, significance and potential cause of RP patients remained elusive. Original Source

Differences in multiple immune parameters between Indian and U.S. infants

To compare immune phenotypes across two geographic and ethnic communities, the researchers examined umbilical cord blood by flow cytometry and Luminex in parallel cohorts of 53 newborns from New Delhi, India, and 46 newborns from Stanford, California. Original Source

COVID-19 Response Bulletin-Ethiopia

Members of the public are being mobilized by the government to donate to the national COVID-19 resource mobilization Initiative set up by the Prime Minister. Cash, food and other supplies are being donated by the public, including the private sector. WHO provided technical support for the development of the National …

BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections. The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated …

Epidemiology of Covid-19 in a long-term care facility in King County, Washington

Long-term care facilities are high-risk settings for severe outcomes from outbreaks of Covid-19, owing to both the advanced age and frequent chronic underlying health conditions of the residents and the movement of health care personnel among facilities in a region.

Heart-on-a-chip model with integrated extra- and intracellular bioelectronics for monitoring cardiac electrophysiology under acute Hypoxia

Researchers demonstrated a bioelectronic heart-on-a-chip model for studying the effects of acute hypoxia on cardiac function. A microfluidic channel enabled rapid modulation of medium oxygenation, which mimicked the regimes induced by a temporary coronary occlusion and reversibly activated hypoxia-related transduction pathways in HL-1 cardiac model cells. Original Source

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

The objective of the study was to delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died.  

Time kinetics of viral clearance and resolution of symptoms in Novel Coronavirus infection

In this study, we aimed to determine the time kinetics of viral clearance in reference to the resolution of symptoms in 16 patients treated in Beijing, China, and show that half of the patients with COVID-19 were viral positive even after resolution of their symptoms. Original Source

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

The objective of the research was to delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. Original Source

Serial interval of COVID-19 among publicly reported confirmed cases

The researchers estimate the distribution of serial intervals for 468 confirmed cases of 2019 novel coronavirus disease reported in China as of February 8, 2020. The mean interval was 3.96 days (95% CI 3.53–4.39 days), SD 4.75 days (95% CI 4.46–5.07 days); 12.6% of case reports indicated presymptomatic transmission.

A trial of Lopinavir–Ritonavir in adults hospitalized with severe Covid-19

Researchers conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of …

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