Reply by Army regarding replacing invasive Kikar species in the Ridge area of Delhi, 23/12/2024

Reply by Army in OA No 782 of 2023 (News item titled Forest Department sends notice to Army HQ for tree offences, which appeared in The Times of India dated 18/12/2023). The report of December 23, 2024 was uploaded to the NGT site on April 17, 2025. The affidavit was …

Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease

The objective of the study was to investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography–mass spectrometry. Original Source

The global burden of tuberculosis: results from the Global Burden of Disease Study 2015

An understanding of the trends in tuberculosis incidence, prevalence, and mortality is crucial to tracking of the success of tuberculosis control programmes and identification of remaining challenges. We assessed trends in the fatal and non-fatal burden of tuberculosis over the past 25 years for 195 countries and territories. Original Source

National policy for treatment of rare diseases

A rare disease is a health condition of particularly low prevalence that affects a small number of people compared with other prevalent diseases in the general population. India, like many other developing countries, currently has no standard definition of rare diseases and since there is no epidemmiological data, there are …

World Malaria Report 2017

The World Malaria Report 2017 draws on data from 91 countries and areas with ongoing malaria transmission. The information is supplemented by data from national household surveys and databases held by other organizations.

The expanding epidemic of HIV-1 in the Russian Federation

In 2017, the Russian Federation (RF) is estimated to have the largest number of HIV-1 infected citizens of any country in Europe. Cumulative reported diagnoses reached over 1.16 million infections by mid-2017, and actual infections, including those that remain undiagnosed and/or unreported, are doubtless substantially higher. In contrast to the …

Fighting for breath - A call to action on childhood pneumonia

This report focuses on what is now the single biggest cause of child deaths through infectious disease. Pneumonia is a disease of poverty. Fatalities are concentrated in the world’s poorest countries. Within those countries it is the poorest and most disadvantaged children who face the greatest risks. This report shows …

Mortality risk after AIDS-defining opportunistic illness among HIV-infected persons—San Francisco, 1981–2012

The objective of the study is to examine whether improved human immunodeficiency virus (HIV) treatment was associated with better survival after diagnosis of AIDS-defining opportunistic illnesses (AIDS-OIs) and how survival differed by AIDS-OI. Original Source

The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis

The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is <100%, leading some HIV-uninfected infants to be incorrectly identified as HIV-infected. The World Health Organization recommends that infants undergo a second NAAT to confirm any positive test result, but implementation is limited. …

Improved diagnostics fail to halt the rise of tuberculosis

TB remains a big killer despite the development of a better test for detecting the disease. Original Source

Moscow declaration to end TB

The WHO Global Ministerial Conference “Ending TB in the Sustainable Development Era: A Multisectoral Response” aims to accelerate implementation of the WHO End TB Strategy - with immediate action addressing gaps in access to care and the MDR-TB crisis - in order to reach the End TB targets set by …

Assessing current temporal and space-time anomalies of disease incidence

Approaches used to early and accurately characterize epidemiologic patterns of disease incidence in a temporal and spatial series are becoming increasingly important. Cluster tests are generally designed for retrospective detection of epidemiologic anomalies in a temporal or space-time series. Timely identification of anomalies of disease or poisoning incidence during ongoing …

Genetic testing and common disorders in a public health framework: how to assess relevance and possibilities

During the years prior to the turn of the century, scientific and medical attention for genetic disorders was mainly focused on understanding rare single-gene disorders, such as Huntington's disease, Duchenne muscular dystrophy, and cystic fibrosis (CF), as well as chromosomal abnormalities. The medical specialty of clinical genetics was established in …

Effectiveness of cervical screening after age 60 years according to screening history: Nationwide cohort study in Sweden

The relatively high incidence of cervical cancer in women at older ages is a continuing concern in countries with long-established cervical screening. Controversy remains on when and how to cease screening. Existing population-based studies on the effectiveness of cervical screening at older ages have not considered women’s screening history. We …

Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and Anti-Dengue virus IgM antibody

Dengue virus (DENV) infection occurs throughout tropical and sub-tropical regions of the world where dengue is a major public health problem. Laboratory diagnosis of dengue with a single serum specimen obtained during the acute phase of the illness requires tests to detect IgM antibodies to DENV or the virus genome. …

The impact of the roll-out of rapid molecular diagnostic testing for tuberculosis on empirical treatment in Cape Town, South Africa

The objective of the study was to investigate the impact of introducing a rapid test as the first-line diagnostic test for drug-sensitive tuberculosis in Cape Town, South Africa. Original Source

Scrub typhus meningitis in south India — A retrospective study

Scrub typhus is prevalent in India although definite statistics are not available. There has been only one study on scrub typhus meningitis 20 years ago. Most reports of meningitis/meningoencephalitis in scrub typhus are case reports A retrospective study done in Pondicherry to extract cases of scrub typhus admitted to hospital …

Issues raised by the incidence and survival of childhood cancers

An Article by Audrey Bonaventure and colleagues in the Lancet Haematology provides international comparisons of 5-year net survival statistics of children diagnosed with leukaemia, and another Article by Eva Steliarova-Foucher and colleagues in the Lancet Oncology is an exhaustive report on worldwide incidence rates of childhood cancers observed in 2001–10. …

Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: a multicentre study

The population of India is extremely diverse comprising of more than 3,000 ethnic groups who still follow endogamy. Haemoglobinopathies are the commonest hereditary disorders in India and pose a major health problem. The data on the prevalence of β-thalassemias and other haemoglobinopathies in different caste/ethnic groups of India is scarce. …

Cathepsin L and B as potential markers for liver fibrosis: Insights from patients and experimental models

Cathepsin L (CTSL) and B (CTSB) have a crucial role in extracellular matrix (ECM) degradation and tissue remodeling, which is a prominent feature of fibrogenesis. The aim of this study was to determine the role and clinical significance of these cathepsins in liver fibrosis. Original Source

Development of a simple noninvasive model to predict significant fibrosis in patients with chronic Hepatitis B: Combination of ultrasound elastography, serum biomarkers, and individual characteristics

The accurate assessment of liver fibrosis is clinically important in patients with chronic hepatitis B (CHB). Blood tests and elastography are now widely used for the noninvasive diagnosis of liver fibrosis in CHB patients. The aim of this study was to develop a new and more accurate predictive model, which …

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